Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., van den Berg, A.J.J., Liskamp, R.M.J. and Pieters, R. (2002) Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic and Medicinal Chemistry Letters, 12(12), pp. 1567-1570. (doi: 10.1016/S0960-894X(02)00245-7)
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Abstract
Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
| Authors: | Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., van den Berg, A.J.J., Liskamp, R.M.J., and Pieters, R. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Bioorganic and Medicinal Chemistry Letters |
| ISSN: | 0960-894X |
| ISSN (Online): | 1464-3405 |
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