Merkx, R., Rijkers, D.T.S., Kemmink, J. and Liskamp, R.M.J. (2003) Chemoselective coupling of peptide fragments using the Staudinger ligation. Tetrahedron Letters, 44(24), pp. 4515-4518. (doi: 10.1016/S0040-4039(03)01014-1)
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Publisher's URL: http://dx.doi.org/10.1016/S0040-4039(03)01014-1
Abstract
Here we report the first Staudinger ligations which yield tetra- and pentapeptides starting from N-terminal α-azido peptides and C-terminal peptideo-(diphenylphosphine)phenyl esters. Mass spectrometric analysis of the reaction mixture provided a better insight into the mechanism of the Staudinger ligation and has been used to explain the observed intermediates and to optimize the ligation reaction. As a result, the optimized reaction enables the chemoselective coupling of peptides containing amino acids other than glycine at the ligation site.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Merkx, R., Rijkers, D.T.S., Kemmink, J., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Tetrahedron Letters |
ISSN: | 0040-4039 |
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