Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z

Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z. Organic Letters, 7(14), pp. 2961-2964. (doi: 10.1021/ol0508781)

Abstract

Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4−7 amino acid residues in yields ranging from 18 to 82%.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Organic Letters
• ISSN: 1523-7060