Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J. and Pieters, R.J. (2006) A new chemical probe for the detection of the cancer-linked galectin-3. Organic and Biomolecular Chemistry, 4, pp. 4387-4394. (doi: 10.1039/b611050a)
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Abstract
A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via ‘click’ chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J., and Pieters, R.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Organic and Biomolecular Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-0520 |
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