Strong inhibition of cholera toxin by multivalent GM1 derivatives

Pukin, A.V., Branderhorst, H.M., Sisu, C., Weijers, C.A.G.M., Gilbert, M., Liskamp, R.M.J. , Visser, G.M., Zuilhof, H. and Pieters, R.J. (2007) Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8(13), pp. 1500-1503. (doi: 10.1002/cbic.200700266)

Abstract

Sticky fingers. The optimal ligand for the cholera toxin (CT), GM1-oligosaccharide (GM1os), was linked to dendritic structures that contained long spacer arms by using highly efficient “click” chemistry coupling. In the inhibition studies very large multivalency effects were observed; the best structure was an unprecedented 380 000-fold more potent ligand for the toxin than a monovalent GM1os derivative.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Pukin, A.V., Branderhorst, H.M., Sisu, C., Weijers, C.A.G.M., Gilbert, M., Liskamp, R.M.J., Visser, G.M., Zuilhof, H., and Pieters, R.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: ChemBioChem
• ISSN: 1439-4227
• ISSN (Online): 1439-7633