Arnusch, C.J., Branderhorst, H., de Kruijff, B., Liskamp, R.M.J. , Breukink, E. and Pieters, R.J. (2007) Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), pp. 13437-13442. (doi: 10.1021/bi7015553)
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Abstract
The pore-forming antibacterial peptide magainin 2 was made divalent, tetravalent, and octavalent via a copper(I)-mediated 1−3 dipolar cycloaddition reaction (“click” chemistry). This series of pore-forming compounds was tested in vitro for their ability to form pores in large unilamillar vesicles (LUVs). A large increase in the pore-forming capability was especially observed with the tetravalent and octavalent magainin compounds in the LUVs consisting of DOPC, and the octavalent magainin compound showed a marked increase with the DOPC/DOPG LUVs. Activity was observed in the low nanomolar range for these compounds.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Arnusch, C.J., Branderhorst, H., de Kruijff, B., Liskamp, R.M.J., Breukink, E., and Pieters, R.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Biochemistry |
Publisher: | American Chemical Society |
ISSN: | 0006-2960 |
ISSN (Online): | 1520-4995 |
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