Elgersma, R.C., Mulder, G.E., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin(20–29). Tetrahedron Letters, 49(6), pp. 987-991. (doi: 10.1016/j.tetlet.2007.12.021)
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Abstract
Factors that determine the chirality of supramolecular helical tapes formed by a backbone-modified amylin(20–29) depsipeptide and inverso-depsipeptide, were studied by Fourier transform infrared spectroscopy, circular dichroism and transmission electron microscopy. Although β-sheet propensity was absent in both peptides, it was found that the l-depsipeptide formed left-handed and the enantiomeric d-depsipeptide right-handed helical tapes. Moreover, the backbone-modified depsipeptides, showed a certain degree of cross-recognition between both enantiomers, which might have implications in designing amyloid formation inhibitors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
| Authors: | Elgersma, R.C., Mulder, G.E., Posthuma, G., Rijkers, D.T.S., and Liskamp, R.M.J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Tetrahedron Letters |
| ISSN: | 0040-4039 |
| ISSN (Online): | 1873-3581 |
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