Murcia, P.R. et al. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), pp. 4768-4771. (doi: 10.1128/JVI.03379-12)
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Abstract
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Baillie, Professor George and Murcia, Professor Pablo |
Authors: | Murcia, P.R., Baillie, G.J., Stack, J.C., Jervis, C., Elton, D., Mumford, J.A., Daly, J., Kellam, P., Grenfell, B.T., Holmes, E.C., and Wood, J.L.N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of Virology |
ISSN: | 0022-538X |
ISSN (Online): | 1098-5514 |
Published Online: | 06 February 2013 |
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