Bennett, D., Eckersall, P. D. , Waterston, M., Marchetti, V., Rota, A., Mcculloch, E. and Sbrana, S. (2013) The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis. BMC Veterinary Research, 9(42), (doi: 10.1186/1746-6148-9-42)
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Publisher's URL: http://dx.doi.org/10.1186/1746-6148-9-42
Abstract
Background: Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to failure of the cranial cruciate ligament were recruited into this study. Lameness, radiographic features, synovial cytology and C-reactive protein concentrations in serum and synovial fluid were assessed before and 28 days after commencing a course of Robenacoxib at a dose of 1 mg/kg SID.<p></p> Results: There was a significant reduction in the lameness score (P <0.01) and an increase in the radiographic score (P < 0.05) between pre- and post-treatment assessments. There was no difference between pre- (median 1.49 mg/l; Q1-Q3 0.56-4.24 mg/L) and post – (1.10 mg/L; 0.31-1.78 mg/L) treatment serum C-reactive protein levels although synovial fluid levels were significantly reduced (pre- : 0.44 mg/L; 0.23-1.62 mg/L; post- : 0.17 mg/L; 0.05-0.49 mg/L) (P < 0.05). There was no correlation between C-reactive protein concentrations in serum and matched synovial fluid samples.<p></p> Conclusions: Robenacoxib proved effective in reducing lameness in dogs with failure of the cranial cruciate ligament and osteoarthritis of the stifle joint. The drug also reduced levels of C-reactive protein in the synovial fluid taken from the affected stifle joint. Robenacoxib appears to reduce articular inflammation as assessed by C-reactive protein which supports the concept that Robenacoxib is a tissue-selective non-steroidal anti-inflammatory drug.<p></p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Eckersall, Professor David and Waterston, Miss Mary and Bennett, Professor David and Mcculloch, Miss Eilidh |
Authors: | Bennett, D., Eckersall, P. D., Waterston, M., Marchetti, V., Rota, A., Mcculloch, E., and Sbrana, S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | BMC Veterinary Research |
Publisher: | BioMed Central Ltd |
ISSN: | 1746-6148 |
Published Online: | 01 March 2013 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in BMC Veterinary Research 9:42 |
Publisher Policy: | Reproduced under a Creative Commons License |
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