The evolutionary role of the IL-33/ST2 system in host immune defence

Sattler, S., Smits, H.H., Xu, D. and Huang, F.-P. (2013) The evolutionary role of the IL-33/ST2 system in host immune defence. Archivum Immunologiae et Therapiae Experimentalis, 61(2), pp. 107-117. (doi: 10.1007/s00005-012-0208-8)

Abstract

Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Xu, Dr Damo
• Authors: Sattler, S., Smits, H.H., Xu, D., and Huang, F.-P.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Archivum Immunologiae et Therapiae Experimentalis
• ISSN: 0004-069X
• ISSN (Online): 1661-4917
• Published Online: 03 January 2013