Tovey, S.M., Brown, S.B., Doughty, J.C., Mallon, E.A., Cooke, T.G. and Edwards, J. (2009) Poor survival outcomes in HER2 positive breast cancer patients with low grade, node negative tumours. British Journal of Cancer, 100(5), pp. 680-683. (doi: 10.1038/sj.bjc.6604940)
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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6604940
Abstract
We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise very good prognostic group. Our results provide support for the use of adjuvant trastuzumab in patients who are typically classified as having very good prognosis, not routinely offered standard chemotherapy, and who as such do not fit current UK prescribing guidelines for trastuzumab.
Item Type: | Articles |
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Keywords: | HER2, breast cancer, trastuzumab |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Edwards, Professor Joanne and Mallon, Dr Elizabeth and Tovey, Ms Sian and Cooke, Prof Timothy |
Authors: | Tovey, S.M., Brown, S.B., Doughty, J.C., Mallon, E.A., Cooke, T.G., and Edwards, J. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | British Journal of Cancer |
Publisher: | Nature Publishing Group |
ISSN: | 0007-0920 |
ISSN (Online): | 1532-1827 |
Published Online: | 17 February 2009 |
Copyright Holders: | Copyright © 2009 Nature Publishing Group |
First Published: | First published in British Journal of Cancer 100(5):680-683 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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