Models of insulin signalling and longevity

Piper, M.D.W., Selman, C. , McElwee, J.J. and Partridge, L. (2005) Models of insulin signalling and longevity. Drug Discovery Today: Disease Models, 2(4), pp. 249-256. (doi: 10.1016/j.ddmod.2005.11.001)

Abstract

Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Selman, Professor Colin
• Authors: Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Drug Discovery Today: Disease Models
• ISSN: 1740-6757