Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Lee, J.S. et al. (2012) Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mechanisms of Ageing and Development, 133(7), pp. 467-478. (doi: 10.1016/j.mad.2012.05.006)

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Abstract

Aging is associated with a loss of cellular homeostasis, a decline in physiological function and an increase in various pathologies. Employing a meta-analysis, hepatic gene expression profiles from four independent mouse aging studies were interrogated. There was little overlap in the number of genes or canonical pathways perturbed, suggesting that independent study-specific factors may play a significant role in determining age-dependent gene expression. However, 43 genes were consistently altered during aging in three or four of these studies, including those that (1) exhibited progressively increased expression starting from 12 months of age, (2) exhibited similar expression changes in models of progeria at young ages and dampened or no changes in old longevity mouse models, (3) were associated with inflammatory tertiary lymphoid neogenesis (TLN) associated with formation of ectopic lymphoid structures observed in chronically inflamed tissues, and (4) overlapped with genes perturbed by aging in brain, muscle, and lung. Surprisingly, around half of the genes altered by aging in wild-type mice exhibited similar expression changes in adult long-lived mice compared to wild-type controls, including those associated with intermediary metabolism and feminization of the male-dependent gene expression pattern. Genes unique to aging in wild-type mice included those linked to TLN.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin
Authors: Lee, J.S., Ward, W.O., Ren, H., Vallanat, B., Darlington, G.J., Han, E., Laguna, J.C., DeFord, J.H., Papaconstantinou, J., Selman, C., and Corton, J.C.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Mechanisms of Ageing and Development
Publisher:Elsevier Ireland Ltd
ISSN:0047-6374
Published Online:13 June 2012

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