Chapter 2 biological and biophysical properties of vascular connexin channels

Johnstone, S.R., Isakson, B. and Locke, D. (2009) Chapter 2 biological and biophysical properties of vascular connexin channels. International Review of Cell and Molecular Biology, 278, pp. 69-118. (doi: 10.1016/S1937-6448(09)78002-5)

Abstract

Intercellular channels formed by connexin proteins play a pivotal role in the direct movement of ions and larger cytoplasmic solutes between vascular endothelial cells, between vascular smooth muscle cells, and between endothelial and smooth muscle cells. Multiple genetic and epigenetic factors modulate connexin expression levels and/or channel function, including cell-type-independent and cell-type-specific transcription factors, posttranslational modifications, and localized membrane targeting. Additionally, differences in protein-protein interactions, including those between connexins, significantly contribute to both vascular homeostasis and disease progression. The biophysical properties of the connexin channels identified in the vasculature, those formed by Cx37, Cx40, Cx43 and/or Cx45 proteins, are discussed in this chapter in the physiological and pathophysiological context of vessel function.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Johnstone, Dr Scott
• Authors: Johnstone, S.R., Isakson, B., and Locke, D.
• Subjects: Q Science > Q Science (General); Q Science > QH Natural history > QH301 Biology; Q Science > QH Natural history > QH345 Biochemistry
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: International Review of Cell and Molecular Biology
• ISSN: 1937-6448