Lemarié, F., Chang, C.W., Blatchford, D.R., Amor, R., Norris, G., Tetley, L., McConnell, G. and Dufès, C. (2013) Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration. Nanomedicine, 8(2), pp. 181-192. (doi: 10.2217/NNM.12.83)
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Abstract
The therapeutic potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol with anticancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study was to determine whether a tumor-targeted vesicular formulation of EGCG would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. Materials & methods: Transferrin-bearing vesicles encapsulating EGCG were administered intravenously to mice bearing subcutaneous A431 and B16-F10 tumors. Results: The intravenous administration of EGCG encapsulated in transferrin-bearing vesicles resulted in tumor suppression in 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared with controls. Conclusion: Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tetley, Dr Laurence |
| Authors: | Lemarié, F., Chang, C.W., Blatchford, D.R., Amor, R., Norris, G., Tetley, L., McConnell, G., and Dufès, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Nanomedicine |
| ISSN: | 1743-5889 |
| Published Online: | 14 August 2012 |
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