Lee, L.C.Y., Maurice, D.H. and Baillie, G.S. (2013) Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Future Medicinal Chemistry, 5(4), pp. 451-464. (doi: 10.4155/fmc.12.216)
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Publisher's URL: http://dx.doi.org/10.4155/fmc.12.216
Abstract
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells. In the heart, cAMP participates in the fine control of excitation–contraction coupling, hence, any disregulation of this signaling cascade can lead to cardiac disease. Due to the ubiquitous nature of the cAMP pathway, general inhibitors of cAMP signaling proteins such as PKA, EPAC and PDEs would act non-specifically and universally, increasing the likelihood of serious ‘off target’ effects. Recent advances in the discovery of peptides and small molecules that disrupt the protein–protein interactions that underpin cellular targeting of cAMP signaling proteins are described and discussed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baillie, Professor George |
| Authors: | Lee, L.C.Y., Maurice, D.H., and Baillie, G.S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Future Medicinal Chemistry |
| ISSN: | 1756-8919 |
| Published Online: | 01 March 2013 |
| Copyright Holders: | Copyright © 2013 Future Science |
| First Published: | First published in Future Medicinal Chemistry 5(4):451-464 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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