Kennedy, S. , Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi: 10.1016/j.pharmthera.2013.01.001)
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Abstract
Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lawrence, Dr Catherine and Kennedy, Professor Simon and Maffia, Professor Pasquale |
| Authors: | Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E., and Maffia, P. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RM Therapeutics. Pharmacology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Pharmacology and Therapeutics |
| ISSN: | 0163-7258 |
| Published Online: | 16 January 2013 |
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