Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer

Roxburgh, C.S.D. , Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G. and McMillan, D.C. (2009) Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer. British Journal of Cancer, 100(5), pp. 701-706. (doi: 10.1038/sj.bjc.6604926)

Abstract

After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and C disease. Similarly, the modified Glasgow Prognostic Score (mGPS) based on biochemical criteria has also been validated. This study compares both the scores in patients undergoing curative resection of colon cancer. A total of 244 patients underwent elective resection between 1997 and 2005. The PI was constructed from pathological reports; the mGPS was measured pre-operatively. The median follow-up was 67 months (minimum 36 months) during which 109 patients died; 68 of them from cancer. On multivariate analysis of age, Dukes' stage, PI and mGPS, age (hazard ratio, HR, 1.74, P=0.001), Dukes' stage (HR, 3.63, P<0.001), PI (HR, 2.05, P=0.010) and mGPS (HR, 2.34, P<0.001) were associated independently with cancer-specific survival. Three-year cancer-specific survival rates for Dukes' B patients with the low-risk PI were 98, 92 and 82% for the mGPS of 0, 1 and 2, respectively (P<0.05). The high-risk PI population is small, in particular for Dukes' B disease (9%). The mGPS further stratifies those patients classified as low risk by the PI. Combining both the scoring systems could identify patients who have undergone curative surgery but are at high-risk of cancer-related death, therefore guiding management and trial stratification.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMillan, Professor Donald and Roxburgh, Professor Campbell
• Authors: Roxburgh, C.S.D., Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G., and McMillan, D.C.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: British Journal of Cancer
• Journal Abbr.: Br J Cancer
• Publisher: Nature Publishing Group
• ISSN: 0007-0920
• Published Online: 10 February 2009
• Copyright Holders: Copyright © 2009 Nature Publishing Group
• First Published: First published in British Journal of Cancer 100(5):701-706
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.