Structure and properties of methacrylate-endcapped caprolactone networks with modulated water uptake for biomedical applications

Escobar Ivirico, J.L., Costa Martínez, E., Salmerón-Sánchez, M. , Muñoz Criado, I., Gómez Ribelles, J.L. and Monleón Pradas, M. (2007) Structure and properties of methacrylate-endcapped caprolactone networks with modulated water uptake for biomedical applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 83B(1), pp. 266-275. (doi: 10.1002/jbm.b.30792)

Abstract

Methacrylate-endcapped caprolactone (CLMA) networks were synthesized and copolymerized with 2-hydroxyethyl acrylate (HEA) seeking to tailor the hydrophilicity of the system. The resulting structure of the copolymer network is investigated by differential scanning calorimetry, thermogravimetry, and Fourier transform infrared spectroscopy. The dynamic swelling behavior and the equilibrium water sorption is measured and correlated with the microstructure. The experimental results allow one to conclude that the new material is a random copolymer of both components, HEA and CLMA. The effect of cell attachment and proliferation on the new copolymer networks was observed by in vitro culture of human chondrocytes up to 8 days. Enhanced cellular adhesion, similar to that obtained with tissue culture polystyrene (TCPS), was obtained in the hydrophilized systems. The new copolymers are appropriate for the fabrication of scaffolds with controlled porosity for tissue engineering.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Salmeron-Sanchez, Professor Manuel
• Authors: Escobar Ivirico, J.L., Costa Martínez, E., Salmerón-Sánchez, M., Muñoz Criado, I., Gómez Ribelles, J.L., and Monleón Pradas, M.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Journal of Biomedical Materials Research Part B: Applied Biomaterials
• ISSN: 1552-4973
• Published Online: 02 April 2007