Crossed cerebellar diaschisis: insights into oxygen challenge MRI

Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M. and Muir, K.W. (2012) Crossed cerebellar diaschisis: insights into oxygen challenge MRI. Journal of Cerebral Blood Flow and Metabolism, 32(12), pp. 2114-2117. (doi:10.1038/jcbfm.2012.142)

Full text not currently available from Enlighten.

Abstract

Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muir, Professor Keith and Brennan, Dr David and Hadley, Professor Donald and Dani, Dr Krishna and Santosh, Dr Celestine
Authors: Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M., and Muir, K.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Publisher:Nature Publishing Group
ISSN:0271-678X
ISSN (Online):1559-7016

University Staff: Request a correction | Enlighten Editors: Update this record