Sangal, V. et al. (2013) Global phylogeny of shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology, 51(1), pp. 303-305. (doi: 10.1128/JCM.02238-12)
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Abstract
The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brown, Dr Derek |
| Authors: | Sangal, V., Holt, K. E., Yuan, J., Brown, D.J., Filliol-Toutain, I., Weill, F.-X., Kim, D.-W., da Silveira, W. D., Pickard, D., Thomson, N. R., Parkhill, J., and Yu, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Clinical Microbiology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0095-1137 |
| ISSN (Online): | 1098-660X |
| Published Online: | 31 October 2012 |
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