GPCR theme editorial

Milligan, G. and McGrath, J.C. (2009) GPCR theme editorial. British Journal of Pharmacology, 158(1), pp. 1-4. (doi: 10.1111/j.1476-5381.2009.00422.x)

Abstract

This themed section of BJP includes 11 reviews on the biology of G-protein coupled receptors (GPCRs) and the drug targets that these present, 21 research papers on the pharmacology of a range of GPCRs and commentaries on four of the papers. Areas reviewed include molecular interactions, particular in respect of hetero-dimerisation between receptors and other membrane-located proteins and other key signalling molecules including cAMP and G12/13 proteins and recently de-orphanised receptors including the Neuromedins U and S and the Free Fatty Acid receptors FFA2 and FFA3. The research papers cover the pharmacology of a range of agents acting at GPCRs, including adrenoceptors, purinoceptors, 5HT, opioid, cannabinoid and PAR-2 receptors. A group of papers is concerned with the interesting and rapidly developing pharmacology of drugs acting at β₂-adrenoceptors. The reach of GPCRs is illustrated by the range of physiological systems and therapeutic applications involved, including pain, cancer, cardiovascular, gastrointestinal, visual and respiratory and central nervous systems.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McGrath, Professor John and Milligan, Professor Graeme
• Authors: Milligan, G., and McGrath, J.C.
• Subjects: Q Science > QH Natural history > QH345 Biochemistry; Q Science > QH Natural history > QH301 Biology
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience; College of Medical Veterinary and Life Sciences > School of Life Sciences
• Journal Name: British Journal of Pharmacology
• Journal Abbr.: Brit J Pharmacol
• ISSN: 0007-1188
• Published Online: 25 August 2009