McCulloch, R. and Horn, D. (2009) What has DNA sequencing revealed about the VSG expression sites of African trypanosomes? Trends in Parasitology, 25(8), pp. 359-363. (doi: 10.1016/j.pt.2009.05.007)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1016/j.pt.2009.05.007
Abstract
Antigenic variation is crucial for the survival of African trypanosomes in mammals and involves switches in expression of variant surface glycoprotein genes, which are co-transcribed with a number of expression-site-associated genes (<i>ESAG</i>s) from loci termed 'blood-stream expression sites' (BESs). Trypanosomes possess multiple BESs, although the reason for this (and why <i>ESAG</i>s are resident in these loci) has remained a subject of debate. The genome sequence of <i>Trypanosoma brucei</i>, released in 2005, did not include the BESs because of their telomeric disposition. This gap in our knowledge has now been bridged by two new studies, which we discuss here, asking what has been revealed about the biological significance of BES multiplicity and <i>ESAG</i> function and evolution
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McCulloch, Professor Richard and Horn, Mr David |
| Authors: | McCulloch, R., and Horn, D. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Related URLs: |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric