Al-Rawhani, M., Chitnis, D., Beeley, J., Collins, S. and Cumming, D. (2013) Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues. IEEE Transactions on Biomedical Engineering, 60(1), pp. 55-62. (doi: 10.1109/TBME.2012.2222641)
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Abstract
We report on the design, fabrication, testing, and packaging of a miniaturized system capable of detecting autofluorescence (AF) from mammalian intestinal tissue. The system comprises an application-specific integrated circuit (ASIC), light-emitting diode, optical filters, control unit, and radio transmitter. The ASIC contains a high-voltage charge pump and single-photon avalanche diode detector (SPAD). The charge pump biases the SPAD above its breakdown voltage to operate in Geiger mode. The SPAD offers a photon detection efficiency of 37% at 520 nm, which corresponds to the AF emission peak of the principle human intestinal fluorophore, flavin adenine dinucleotide. The ASIC was fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3 V and draws an average of 7.1 mA, enabling up to 23 h of continuous operation from two 165-mAh SR44 batteries.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Al-Rawhani, Dr Mohammed and Cumming, Professor David and Beeley, Dr James |
Authors: | Al-Rawhani, M., Chitnis, D., Beeley, J., Collins, S., and Cumming, D. |
College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
Journal Name: | IEEE Transactions on Biomedical Engineering |
ISSN: | 0018-9294 |
Published Online: | 20 December 2012 |
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