Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis?

Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

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Plasmacytoid dendritic cells (pDCs) represent a unique subset of dendritic cells that play distinct and critical roles in the immune response. Importantly, pDCs play a pivotal role in several chronic autoimmune diseases strongly characterized by an increased risk of vascular pathology. Clinical studies have shown that pDCs are detectable in atherosclerotic plaques and others have suggested an association between reduced numbers of circulating pDCs and cardiovascular events. Although the causal relationship between pDCs and atherosclerosis is still uncertain, recent results from mouse models are starting to define the specific role(s) of pDCs in the disease process. In this review, we will discuss the role of pDCs in innate and adaptive immunity, the emerging evidence demonstrating the contribution of pDCs to vascular pathology and we will consider the possible impact of pDCs on the acceleration of atherosclerosis in chronic inflammatory autoimmune diseases. Finally, we will discuss how pDCs could be targeted for therapeutic utility.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Garside, Professor Paul and Brewer, Professor James and Platt, Dr Andrew and MacRitchie, Dr Neil and Maffia, Professor Pasquale and Grassia, Dr Gianluca
Authors: Grassia, G., MacRitchie, N., Platt, A., Brewer, J., Garside, P., and Maffia, P.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Pharmacology and Therapeutics
ISSN (Online):1879-016X
Published Online:08 October 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
524831Visualising antigen presentation in mouse models of atherosclerosisPasquale MaffiaMedical Research Scotland (MED-SCOT)276 FRGIII -IMMUNOLOGY
404921Investigating the role of T cells in vascular pathologyPaul GarsideBritish Heart Foundation (BHF)PG/06/083/21198III -IMMUNOLOGY