Consolidated and labile odor memory are separately encoded within the drosophila brain

Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi: 10.1523/JNEUROSCI.3286-12.2012)

Abstract

Memories are classified as consolidated (stable) or labile according to whether they withstand amnestic treatment, or not. In contrast to the general prevalence of this classification, its neuronal and molecular basis is poorly understood. Here, we focused on consolidated and labile memories induced after a single cycle training in the Drosophila aversive olfactory conditioning paradigm and we used mutants to define the impact of cAMP signals. At the biochemical level we report that cAMP signals misrelated in either rutabaga (rut) or dunce (dnc) mutants separate between consolidated anesthesia-resistant memory (ARM) and labile anesthesia-sensitive memory (ASM). Those functionally distinct cAMP signals act within different neuronal populations: while rut-dependent cAMP signals act within Kenyon cells (KCs) of the mushroom bodies to support ASM, dnc-sensitive cAMP signals support ARM within antennal lobe local neurons (LNs) and KCs. Collectively, different key positions along the olfactory circuitry seem to get modified during storage of ARM or ASM independently. A precise separation between those functionally distinct cAMP signals seems mandatory to allocate how they support appropriate memories.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sebastian, Mr Sujith and Day, Dr Jonathan and Davies, Professor Shireen
• Authors: Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A., and Schwarzel, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Journal of Neuroscience
• Publisher: The Society for Neuroscience
• ISSN: 0270-6474
• ISSN (Online): 1529-2401