Baker, L. et al. (2010) p53 mutation, deprivation and poor prognosis in primary breast cancer. British Journal of Cancer, 102(4), pp. 719-726. (doi: 10.1038/sj.bjc.6605540)
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Abstract
Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived communities. methods: p53 mutation status was determined using the Roche Amplichip research test in 246 women with primary breast cancer attending a single cancer centre and related to deprivation, pathology, overall, and disease-free survival. results: p53 mutation, identified in 64/246 (26%) of cancers, was most common in 10 out of 17 (58.8%) of the lowest (10th) deprivation decile. Those patients with p53 mutation in the 10th decile had a significantly worse disease-free survival of only 20% at 5 years (Kaplan–Meier logrank χ2=6.050, P=0.014) and worse overall survival of 24% at 5 years (Kaplan–Meier logrank χ2=6.791, P=0.009) than women of deciles 1–9 with p53 mutation (c.f. 56% and 72%, respectively) or patients in the 10th decile with wild-type p53 (no disease relapse or deaths). conclusion: p53 mutation in breast cancer is associated with socio-economic deprivation and may provide a molecular basis, with therapeutic implications, for the poorer outcome in women from deprived communities.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mccowan, Professor Colin |
| Authors: | Baker, L., Quinlan, P.R., Patten, N., Ashfield, A., Birse-Stewart-Bell, L.-J., Mccowan, C., Bourdon, J.-C., Purdie, C.A., Jordan, L.B., Dewar, J.A., Wu, L., and Thompson, A.M. |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | British Journal of Cancer |
| Publisher: | Nature Publishing Group |
| ISSN: | 0007-0920 |
| ISSN (Online): | 1532-1827 |
| Published Online: | 26 January 2010 |
| Copyright Holders: | Copyright © 2010 Cancer Research UK |
| First Published: | First published in British Journal of Cancer 102(4):719-726 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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