Sirtuins of parasitic protozoa: in search of function(s)

Religa, A.A. and Waters, A.P. (2012) Sirtuins of parasitic protozoa: in search of function(s). Molecular and Biochemical Parasitology, 185(2), pp. 71-88. (doi:10.1016/j.molbiopara.2012.08.003)

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Abstract

The SIR2 family of NAD<sup>+</sup>-dependent protein deacetylases, collectively called sirtuins, has been of central interest due to their proposed roles in life-span regulation and ageing. Sirtuins are one group of environment sensors of a cell interpreting external information and orchestrating internal responses at the sub-cellular level, through participation in gene regulation mechanisms. Remarkably conserved across all kingdoms of life SIR2 proteins in several protozoan parasites appear to have both conserved and intriguing unique functions. This review summarises our current knowledge of the members of the sirtuin families in Apicomplexa, including Plasmodium, and other protozoan parasites such as Trypanosoma and Leishmania. The wide diversity of processes regulated by SIR2 proteins makes them targets worthy of exploitation in anti-parasitic therapies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Waters, Professor Andy and Religa, Miss Agnieszka
Authors: Religa, A.A., and Waters, A.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN:0166-6851
ISSN (Online):1872-9428
Published Online:10 August 2012

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