The kinomes of apicomplexan parasites

Miranda-Saavedra, D., Gabaldón, T., Barton, G., Langsley, G. and Doerig, C. (2012) The kinomes of apicomplexan parasites. Microbes and Infection, 14(10), pp. 796-810. (doi: 10.1016/j.micinf.2012.04.007)

Abstract

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.

• Item Type: Articles
• Additional Information: “NOTICE: this is the author’s version of a work that was accepted for publication in Microbes and Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Microbes and Infection, 14(10) 2012. 10.1016/j.micinf.2012.04.007 "
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Doerig, Dr Christian
• Authors: Miranda-Saavedra, D., Gabaldón, T., Barton, G., Langsley, G., and Doerig, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Microbes and Infection
• Publisher: Elsevier on behalf of Institut Pasteur
• ISSN: 1286-4579
• ISSN (Online): 1769-714X
• Published Online: 26 April 2012
• Copyright Holders: Copyright © 2012 Institut Pasteur
• First Published: First published in Microbes and Infection 14(10):796-810
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher