Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling

Lim, D.C., Cooke, B.M., Doerig, C. and Saeij, J.P.J. (2012) Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. International Journal for Parasitology, 42(1), pp. 21-32. (doi: 10.1016/j.ijpara.2011.11.007)

Abstract

Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).

• Item Type: Articles
• Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in International Journal for Parasitology . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal for Parasitology, 41(1)2012. 10.1016/j.ijpara.2011.11.007" Title on full text PDF differs from final published title.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Doerig, Dr Christian
• Authors: Lim, D.C., Cooke, B.M., Doerig, C., and Saeij, J.P.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: International Journal for Parasitology
• Publisher: Elsevier
• ISSN: 0020-7519
• ISSN (Online): 1879-0135
• Copyright Holders: Copyright © 2011 Australian Society for Parasitology Inc
• First Published: First published in International Journal for Parasitology 42(1):21-32
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher