Microrheology with optical tweezers: data analysis

Tassieri, M. , Evans, R.M.L., Warren, R.L., Bailey, N.J. and Cooper, J.M. (2012) Microrheology with optical tweezers: data analysis. New Journal of Physics, 14(11), p. 115032. (doi: 10.1088/1367-2630/14/11/115032)

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We present a data analysis procedure that provides the solution to a long-standing issue in microrheology studies, i.e. the evaluation of the fluids' linear viscoelastic properties from the analysis of a finite set of experimental data, describing (for instance) the time-dependent mean-square displacement of suspended probe particles experiencing Brownian fluctuations. We report, for the first time in the literature, the linear viscoelastic response of an optically trapped bead suspended in a Newtonian fluid, over the entire range of experimentally accessible frequencies. The general validity of the proposed method makes it transferable to the majority of microrheology and rheology techniques.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bailey, Dr Nicholas and Cooper, Professor Jonathan and Tassieri, Dr Manlio
Authors: Tassieri, M., Evans, R.M.L., Warren, R.L., Bailey, N.J., and Cooper, J.M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:New Journal of Physics
Publisher:Institute of Physics Publishing Ltd.
Copyright Holders:Copyright © 2012 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
First Published:First published in New Journal of Physics 14(11):115032
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
Data DOI:10.5525/gla.researchdata.156

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
534472Rheology at the Microscale: New Tools for Bio-analysisManlio TassieriEngineering & Physical Sciences Research Council (EPSRC)10216/101ENG - BIOMEDICAL ENGINEERING