Stevenson, D., Colman, K.L. and Davison, A.J. (1994) Delineation of a sequence required for nuclear localization of the protein encoded by varicella-zoster virus gene 61. Journal of General Virology, 75(11), pp. 3229-3233. (doi: 10.1099/0022-1317-75-11-3229)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1099/0022-1317-75-11-3229
Abstract
All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the CaHC 4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C<sub>3</sub>HC<sub>4</sub> protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Davison, Professor Andrew |
| Authors: | Stevenson, D., Colman, K.L., and Davison, A.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of General Virology |
| Journal Abbr.: | J. Gen. Virol. |
| Publisher: | Society for General Microbiology |
| ISSN: | 0022-1317 |
| ISSN (Online): | 1465-2099 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric