DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus

McGeoch, D.J. and Davison, A.J. (1986) DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus. Nucleic Acids Research, 14(10), pp. 4281-4292. (doi: 10.1093/nar/14.10.4281)

Abstract

We have determined the sequence of herpes simplex virus type 1 DNA around the previously mapped location of sequences encoding an epitope of glycoprotein gH, and have deduced the structure of the gH gene and the amino acid sequence of gH.The unprocessed polypeptide is predicted to contain 838 amino acids, and to possess an N-terminal signal sequence and a C-terminal transmembrane sequence.Temperature-sensitive mutant tsQ26 maps within the predicted gH coding sequence.Homologous genes were identified in the genomes of two other herpesviruses, namely varicella-zoster virus and Epstein-Barr virus.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McGeoch, Professor Duncan and Davison, Professor Andrew
• Authors: McGeoch, D.J., and Davison, A.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Nucleic Acids Research
• Journal Abbr.: Nucl. Acids Res.
• ISSN: 0305-1048
• ISSN (Online): 1362-4962