Genomic location and lack of phosphorylation of the HSV immediate-early polypeptide IE 12

Marsden, H.S., Lang, J., Davison, A.J. , Hope, R.G. and Macdonald, D.M. (1982) Genomic location and lack of phosphorylation of the HSV immediate-early polypeptide IE 12. Journal of General Virology, 62(1), pp. 17-27. (doi: 10.1099/0022-1317-62-1-17)

Abstract

Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE)polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on SDS-polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by five H~V-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/ IE 12.3 mapped in the region spanning the TRs/U s junction. Unlike four other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Davison, Professor Andrew
• Authors: Marsden, H.S., Lang, J., Davison, A.J., Hope, R.G., and Macdonald, D.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of General Virology
• Publisher: Society for General Microbiology
• ISSN: 0022-1317
• ISSN (Online): 1465-2099