Davison, A.J. and Wilkie, N.M. (1983) Either orientation of the L segment of the Herpes Simplex virus genome may participate in the production of viable intertypic recombinants. Journal of General Virology, 64(1), pp. 247-250. (doi: 10.1099/0022-1317-64-1-247)
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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-64-1-247
Abstract
We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Davison, Professor Andrew |
Authors: | Davison, A.J., and Wilkie, N.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of General Virology |
Journal Abbr.: | J. Gen. Virol. |
Publisher: | Society for General Microbiology |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
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