Nucleotide sequences of the joint between the L and S segments of Herpes Simplex virus types 1 and 2

Davison, A.J. and Wilkie, N.M. (1981) Nucleotide sequences of the joint between the L and S segments of Herpes Simplex virus types 1 and 2. Journal of General Virology, 55(2), pp. 315-331. (doi: 10.1099/0022-1317-55-2-315)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-55-2-315

Abstract

The a sequence of herpes simplex virus (HSV) is present as a direct repeat at the genomic termini and also in inverted orientation at thc joint between the L and S segments. DNA sequences have been determined for the joint regions of the genomes of HSV-I and HSV-2, and relative to these sequences the genomic termini are in both cases located close to a short direct repeat of 17 to 21 base pairs (bp) at the b-a and a-c junctions. The HSV-I joint region contains three separate tandem direct reiterations of short sequences, (12, 16 and 17 bp in strain 17) and we conclude that size heterogeneity in'the a and c sequences is due to variable copy numbers of these repeated units. It is likely that a considerable part of the HSV-i joint region does not code for polypeptide.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Davison, Professor Andrew
Authors: Davison, A.J., and Wilkie, N.M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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