Three-dimensional structure of the HSV1 nucleocapsid

Schrag, J.D., Prasad, B.V.V., Rixon, F.J. and Chiu, W. (1989) Three-dimensional structure of the HSV1 nucleocapsid. Cell, 56(4), pp. 651-660. (doi:10.1016/0092-8674(89)90587-4)

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The three-dimensional structures of full and empty capsids of HSV1 were determined by computer analysis of low dose cryo-electron images of ice embedded capsids. The full capsid structure is organized into outer, intermediate, and inner structural layers. The empty capsid structure has only one layer which is indistinguishable from the outer layer of the full capsids. This layer is arranged according to T=16 icosahedral symmetry. The intermediate layer of full capsids appears to lie on a T=4 icosahedral lattice. The genomic DNA is located inside the T=4 shell and is the component of the innermost layer of the full capsids. The outer and intermediate layers interact in such a way that the channels along their icosahedral two-fold axis coincide and form a direct pathway between the DNA and the environment outside the capsid.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Rixon, Dr Frazer
Authors: Schrag, J.D., Prasad, B.V.V., Rixon, F.J., and Chiu, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cell
ISSN (Online):1097-4172

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