Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Holm, C.K. et al. (2012) Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nature Immunology, 13(8), pp. 737-743. (doi: 10.1038/ni.2350) (PMID:22706339) (PMCID:PMC3411909)

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The innate immune system senses infection by detecting either evolutionarily conserved molecules essential for the survival of microbes or the abnormal location of molecules. Here we demonstrate the existence of a previously unknown innate detection mechanism induced by fusion between viral envelopes and target cells. Virus-cell fusion specifically stimulated a type I interferon response with expression of interferon-stimulated genes, in vivo recruitment of leukocytes and potentiation of signaling via Toll-like receptor 7 (TLR7) and TLR9. The fusion-dependent response was dependent on the stimulator of interferon genes STING but was independent of DNA, RNA and viral capsid. We suggest that membrane fusion is sensed as a danger signal with potential implications for defense against enveloped viruses and various conditions of giant-cell formation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Rixon, Dr Frazer
Authors: Holm, C.K., Jensen, S.B., Jakobsen, M.R., Cheshenko, N., Horan, K.A., Moeller, H.B., Gonzalez-Dosal, R., Rasmussen, S.B., Christensen, M.H., Yarovinsky, T.O., Rixon, F.J., Herold, B.C., Fitzgerald, K.A., and Paludan, S.R.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Nature Immunology
Publisher:Nature Publishing Group
ISSN (Online):1529-2916
Published Online:17 June 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656531Structural studies on human virusesFrazer RixonMedical Research Council (MRC)MC_UU_12014/6MVLS III - CENTRE FOR VIRUS RESEARCH