Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)
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Abstract
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control these pathogens. Small RNA-mediated host responses are key players among these antiviral immune strategies. Studies into one such small RNA-mediated antiviral response, the exogenous RNA interference (RNAi) pathway, have generated a wealth of information on the functions of this mechanism and the enzymes which mediate antiviral activities. However, other small RNA-mediated host responses may also be involved in modulating antiviral activity. The aim of this review is to summarize recent research into the nature of small RNA-mediated antiviral responses in mosquitoes and to discuss future directions for this relatively new area of research.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Donald, Dr Claire and Schnettler, Dr Esther and Kohl, Professor Alain |
| Authors: | Donald, C. L., Kohl, A., and Schnettler, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Insects |
| ISSN: | 2075-4450 |
| ISSN (Online): | 2075-4450 |
| Published Online: | 29 May 2012 |
| Copyright Holders: | Copyright © 2012 The Authors |
| First Published: | First published in Insects 3(2):511-531 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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