Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality

Logue, J. , Walker, J.J., Leese, G., Lindsay, R. , McKnight, J., Morris, A., Philip, S., Wild, S. and Sattar, N. (2013) Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality. Diabetes Care, 36(4), pp. 887-893. (doi: 10.2337/dc12-0944)

Abstract

OBJECTIVE: To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to <30 kg/m(2) as a referent group. Deaths within 2 years of BMI determination were excluded. Mean follow-up to death or the end of 2007 was 4.7 years. RESULTS: A total of 9,631 deaths occurred between 2001 and 2007. Compared with reference group, mortality risk was higher in patients with BMI 20 to <25 kg/m(2) (-HR 1.22 [95% CI 1.13-1.32] in men, 1.32 [1.22-1.44] in women) and patients with BMI ≥35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24]) in women for BMI 45 to <50 kg/m(2)). Vascular mortality was higher for each 5-kg/m(2) increase in BMI <30 kg/m(2) by 24% (15-35%) in men and 23% (14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status. CONCLUSIONS: Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight-loss interventions reduce mortality in all T2DM patients requires study.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Leese, Prof Graham and Lindsay, Dr Robert and Logue, Dr Jennifer and Sattar, Professor Naveed
• Authors: Logue, J., Walker, J.J., Leese, G., Lindsay, R., McKnight, J., Morris, A., Philip, S., Wild, S., and Sattar, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes Care
• Publisher: American Diabetes Association
• ISSN: 0149-5992
• ISSN (Online): 1935-5548
• Published Online: 08 November 2012