Imtiaz, T., Lee, K.K., Munro, C.A., MacCallum, D.M., Shankland, G.S., Johnson, E.M., MacGregor, M.S. and Bal, A.M. (2012) Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin. Journal of Medical Microbiology, 61(9), pp. 1330-1334. (doi: 10.1099/jmm.0.045047-0)
Full text not currently available from Enlighten.
Abstract
Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Shankland, Dr Gillian |
| Authors: | Imtiaz, T., Lee, K.K., Munro, C.A., MacCallum, D.M., Shankland, G.S., Johnson, E.M., MacGregor, M.S., and Bal, A.M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Medical Microbiology |
| ISSN: | 0022-2615 |
| Published Online: | 31 May 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric