LV wall segmentation using the variational level set method (LSM) with additional shape constraint for oedema quantification

Kadir, K., Gao, H. , Payne, A., Soraghan, J. and Berry, C. (2012) LV wall segmentation using the variational level set method (LSM) with additional shape constraint for oedema quantification. Physics in Medicine and Biology, 57(19), pp. 6007-6023. (doi: 10.1088/0031-9155/57/19/6007)

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In this paper an automatic algorithm for the left ventricle (LV) wall segmentation and oedema quantification from T2-weighted cardiac magnetic resonance (CMR) images is presented. The extent of myocardial oedema delineates the ischaemic area-at-risk (AAR) after myocardial infarction (MI). Since AAR can be used to estimate the amount of salvageable myocardial post-MI, oedema imaging has potential clinical utility in the management of acute MI patients. This paper presents a new scheme based on the variational level set method (LSM) with additional shape constraint for the segmentation of T2-weighted CMR image. In our approach, shape information of the myocardial wall is utilized to introduce a shape feature of the myocardial wall into the variational level set formulation. The performance of the method is tested using real CMR images (12 patients) and the results of the automatic system are compared to manual segmentation. The mean perpendicular distances between the automatic and manual LV wall boundaries are in the range of 1–2 mm. Bland–Altman analysis on LV wall area indicates there is no consistent bias as a function of LV wall area, with a mean bias of −121 mm<sup>2</sup> between individual investigator one (IV1) and LSM, and −122 mm<sup>2</sup> between individual investigator two (IV2) and LSM when compared to two investigators. Furthermore, the oedema quantification demonstrates good correlation when compared to an expert with an average error of 9.3% for 69 slices of short axis CMR image from 12 patients.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gao, Dr Hao and Payne, Dr Alexander
Authors: Kadir, K., Gao, H., Payne, A., Soraghan, J., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Physics in Medicine and Biology
Publisher:Institute of Physics Publishing Ltd.
ISSN (Online):1361-6560
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
544551Validation and significance of myocardial haemorrhage revealed by "bright blood" T2-weighted MRI in heart attack survivors: a prospective cohort study.Colin BerryBritish Heart Foundation (BHF)PG/11/2/28474RI CARDIOVASCULAR & MEDICAL SCIENCES