Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism

Bratty, M.A., Chintapalli, V.R., Dow, J.A.T. , Zhang, T. and Watson, D.G. (2012) Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism. FEBS Open Bio, 2, pp. 217-221. (doi: 10.1016/j.fob.2012.07.007)

Abstract

Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y. In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dow, Professor Julian and Chintapalli, Dr Venkateswara
• Authors: Bratty, M.A., Chintapalli, V.R., Dow, J.A.T., Zhang, T., and Watson, D.G.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: FEBS Open Bio
• ISSN: 2211-5463