Williams, H., Macsween, K., McAulay, K.A., Higgins, C., Harrison, N., Swerdlow, A., Britton, K. and Crawford, D.H. (2004) Analysis of immune activation and clinical events in acute infectious mononucleosis. Journal of Infectious Diseases, 190(1), pp. 53-62. (doi: 10.1086/421276)
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Publisher's URL: http://dx.doi.org/10.1086/421276
Abstract
The symptoms of infectious mononucleosis (IM) are thought to be caused by T cell activation and cytokine production. Surface lymphocyte activation marker (SLAM)-associated protein (SAP) regulates lymphocyte activation via signals from cell-surface CD244 (2B4) and SLAM (CD150). We followed T cell activation via this SAP/SLAM/CD244 pathway in IM and analyzed whether the results were associated with clinical severity. At diagnosis, SAP, SLAM, and CD244 were significantly up-regulated on CD4 and CD8 T cells; expression decreased during IM, but CD244 and SLAM levels remained higher on CD8 cells 40 days later. There were significantly more lymphocytes expressing CD8 and CD244/CD8 in patients with severe sore throat. The expression of CD8 alone and CD244 on CD8 cells correlated with increased virus load. We suggest that T cells expressing CD244 and SLAM are responsible for the clinical features of IM but that the control of activation is maintained by parallel increased expression of SAP.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McAulay, Dr Karen |
Authors: | Williams, H., Macsween, K., McAulay, K.A., Higgins, C., Harrison, N., Swerdlow, A., Britton, K., and Crawford, D.H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Infectious Diseases |
Journal Abbr.: | J. Infect. Dis. |
Publisher: | Infectious Diseases Society of America |
ISSN: | 0022-1899 |
ISSN (Online): | 1537-6613 |
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