Qualtrough, D., Singh, K., Banu, N., Paraskeva, C. and Pignatelli, M. (2009) The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. British Journal of Cancer, 101(7), pp. 1124-1129. (doi: 10.1038/sj.bjc.6605286)
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Abstract
Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear.<p></p> Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed.<p></p> Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection.<p></p> Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pignatelli, Professor Massimo |
| Authors: | Qualtrough, D., Singh, K., Banu, N., Paraskeva, C., and Pignatelli, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| ISSN (Online): | 1532-1827 |
| Published Online: | 08 September 2009 |
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