Roles for Bmp4 and CaM1 in shaping the jaw: evo-devo and beyond

Parsons, K.J. and Albertson, R.C. (2009) Roles for Bmp4 and CaM1 in shaping the jaw: evo-devo and beyond. Annual Review of Genetics, 43(1), pp. 369-388. (doi:10.1146/annurev-genet-102808-114917)

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Abstract

The craniofacial skeleton, including jaws and beaks, figures prominently in discussions of adaptive divergence. Craniofacial abnormalities also occur in a number of human syndromes, making the development and genetic basis of craniofacial morphology an area of great interest to a wide spectra of biological and medical disciplines. Recent experiments have implicated key roles for Bmp4 and CaM1 in determining the size and shape of craniofacial traits. These factors offer potent new molecular inroads into the processes, mechanisms, and pathways that underlie craniofacial development and the morphogenesis of shape. Here we review this evidence and discuss its use as the basis for a number of new research avenues.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parsons, Dr Kevin
Authors: Parsons, K.J., and Albertson, R.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Annual Review of Genetics
ISSN:0066-4197
ISSN (Online):1545-2948

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