How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models

Porr, B. , McCabe, L., Di Prodi, P., Kolodziejski, C. and Woergoetter, F. (2011) How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models. Neural Networks, 24(6), pp. 560-567. (doi: 10.1016/j.neunet.2011.03.004)

Abstract

It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters. Here we investigate how plasticity is shaped by feedback inhibition in a cortical microcircuit. We use a differential Hebbian learning rule to model spike-timing dependent plasticity and show analytically that the feedback inhibition shortens the time window for LTD during spike-timing dependent plasticity but not for LTP. We then use a realistic GENESIS model to test two hypothesis about interneuron hypofunction and conclude that a reduction in GAD67 is the most likely candidate as the cause for hypofrontality as observed in Schizophrenia.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Di Prodi, Mr Paolo and Porr, Dr Bernd and McCabe, Miss Lynsey
• Authors: Porr, B., McCabe, L., Di Prodi, P., Kolodziejski, C., and Woergoetter, F.
• Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Research Group: Computational neuroscience
• Journal Name: Neural Networks
• Publisher: Elsevier
• ISSN: 0893-6080
• Copyright Holders: Copyright © 2011 Elsevier
• First Published: First published in Neural Networks 2011 24(6):560-567
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher