Fibrin D-dimer and coronary heart disease - prospective study and meta-analysis

Danesh, J., Whincup, P., Walker, M., Lennon, L., Thomson, A., Appleby, P., Rumley, A. and Lowe, G.D.O. (2001) Fibrin D-dimer and coronary heart disease - prospective study and meta-analysis. Circulation, 103(19), pp. 2323-2327.

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Publisher's URL: http://circ.ahajournals.org/cgi/content/abstract/103/19/2323

Abstract

Background<br/>It is unknown whether modest increases of fibrin D- dimer, a circulating marker of fibrin turnover, are relevant to coronary heart disease (CHD) in the general population. <br/>Methods and Results<br/>We measured serum concentrations of D-dimer antigen in the stored baseline blood samples of 630 CHD cases and 1269 controls "nested" in a prospective cohort of 5661 men who were monitored for 16 years, and we conducted a meta-analysis of previous relevant studies to place our findings in context. In a comparison of men in the top third compared with those in the bottom third of baseline fibrin D-dimer values (tertile cutoffs, gt 94 versus lt 49 ng/mL), the odds ratio for CHD was 1.67 (95% CI, 1.31 to 2.13; P lt 0.0001) after adjustments for age and town. The odds ratio increased slightly after further adjustment for smoking, other classic risk factors, and indicators of socioeconomic status (1.79; 95% CI, 1.36 to 2.36). Strong correlations were observed of fibrin D-dimer values with circulating concentrations of C-reactive protein and serum amyloid A protein but not with smoking, blood lipids, blood pressure, and other risk factors. <br/>Conclusion<br/>-Although there may be an association between circulating D-dimer values and CHD, further studies are needed to determine the extent to which this is causal.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rumley, Dr Ann and Lowe, Professor Gordon and Thomson, Dr Alison
Authors: Danesh, J., Whincup, P., Walker, M., Lennon, L., Thomson, A., Appleby, P., Rumley, A., and Lowe, G.D.O.
Subjects:R Medicine > RC Internal medicine
Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Circulation
ISSN:0009-7322

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