Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency

Mackay, V.A. et al. (2012) Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency. Hypertension, 60(4), pp. 1078-1085. (doi: 10.1161/HYPERTENSIONAHA.112.197897)

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Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis. Our aim was to assess how maternal and offspring fatty acid metabolism is altered in mothers in the third trimester of pregnancy with PE (n=62) or intrauterine growth restriction (n=23) compared with healthy pregnancies (n=164). Markers of lipid metabolism and erythrocyte fatty acid concentrations were measured. Maternal adipose tissue fatty acid composition and mRNA expression of adipose tissue fatty acid–metabolizing enzymes and placental fatty acid transporters were compared. Mothers with PE had higher plasma triglyceride (21%, P<0.001) and nonesterified fatty acid (50%, P<0.001) concentrations than controls. Concentrations of major n−6 and n−3 long-chain polyunsaturated fatty acids in erythrocytes were 23% to 60% lower (all P<0.005) in PE and intrauterine growth restriction mothers and offspring compared with controls. Subcutaneous adipose tissue Δ−5 and Δ−6 desaturase and very long-chain fatty acid elongase mRNA expression was lower in PE than controls (respectively, mean [SD] control 3.38 [2.96] versus PE 1.83 [1.91], P=0.030; 3.33 [2.25] versus 1.03 [0.96], P<0.001; 0.40 [0.81] versus 0.00 [0.00], P=0.038 expression relative to control gene [square root]). Low maternal and fetal long-chain polyunsaturated fatty acid concentrations in PE may be the result of decreased maternal synthesis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jordan, Mrs Fiona and Freeman, Dr Dilys and Meyer, Dr Barbara and Mackay, Dr Vanessa and Greer, Prof Ian and Huda, Dr Shahzya
Authors: Mackay, V.A., Huda, S.S., Stewart, F.M., Tham, K., McKenna, L.A., Martin, I., Jordan, F., Brown, E.A., Hodson, L., Greer, I.A., Meyer, B.J., and Freeman, D.J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Hypertension
Publisher:American Heart Association
ISSN (Online):1524-4563
Published Online:04 September 2012
Copyright Holders:Copyright © 2012 American Heart Association
First Published:First published in Hypertension 60(4):1078-1085
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
341641Are microparticles related to the increased expression of cardiovascular risk factors acquired in pre-eclampsia?Dilys FreemanBritish Heart Foundation (BHF)PG/02/167/14801MVLS MED -HUMAN NUTRITION
366741Adipocyte lipolysis as a candidate pathway in the pathogenesis of pre-eclampsiaNaveed SattarBritish Heart Foundation (BHF)PG/03/147/16351RI CARDIOVASCULAR & MEDICAL SCIENCES