Asquith, D.L., Miller, A.L., McInnes, I.B. and Liew, F.Y. (2009) Autoimmune disease: rheumatoid arthritis. Animal models of rheumatoid arthritis. European Journal of Immunology, 39, pp. 1991-2058.
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Abstract
Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These models include the induced arthritis models such as collagen-induced arthritis, collagenantibody- induced arthritis, zymosaninduced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis models such as the TNF-a-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these animal models and discuss their advantages and limitations.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liew, Prof Foo and McInnes, Professor Iain and Asquith, Dr Darren and Miller, Dr Ashley |
| Authors: | Asquith, D.L., Miller, A.L., McInnes, I.B., and Liew, F.Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | European Journal of Immunology |
| ISSN: | 0014-2980 |
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